How you format the content (they way it is displayed to your audience) may again be determined by what system you are using to send your newsletter. If you know some HTML and want to format your newsletter that way, most email programs will support that, but be sure to test your mailing first to several contacts on different mail services. You may even use HTML to include some images directly in the email, but again, this should be tested.
The more complicated your design gets, the more issues that can arise as you view your newsletter in different software programs and web sites. If you wish to keep it simple, using formatting such as all caps for titles to break up your content. Regardless of the method, it’s important that the newsletter is easy to scan and read.